{"product_id":"abcam-ab171097","title":"Abcam, ab171097, FITC Anti-TCR V delta 1 antibody [TS8.2]","description":"\u003cp\u003eSize: 200Test\u003cbr\u003e\nMouse Monoclonal TRDC antibody - conjugated to FITC. Suitable for IHC, Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human TRDC.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:TS8.2,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nConjugation:FITC,\u003cbr\u003e\nExcitation\/Emission:Ex: 495nm, Em: 519nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt, IHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Full Length Protein corresponding to Human TRDC. The exact immunogen used to generate this antibody is proprietary information.B7Z8K6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe TCR V delta 1 or T-cell receptor Vδ1 is a subunit of the gamma-delta T-cell receptor complex. This protein is important in recognizing antigens that are not processed and presented by MHC complexes. TCR V delta 1 weighs around 60 kDa and is mainly expressed on a subset of gamma-delta T cells primarily in mucosal tissues like the skin intestines and lungs. These locations allow it to participate in immune surveillance and responses against pathogens and cancer cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTCR V delta 1 is integral to the function of gamma-delta T cells which play a unique role in the immune response by recognizing stressed cells and presenting non-peptide antigens. Unlike alpha-beta T cells gamma-delta T cells often involving TCR V delta 1 do not require antigen presentation via MHC molecules. Therefore they can respond faster to certain pathological conditions. TCR V delta 1 pairs with the gamma chain in the receptor complex influencing the activation and proliferation of these T cells and modulating immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nTCR V delta 1 participates in key immune processes such as the recognition of phosphoantigens and stress-induced ligands through pathways like the Vδ1 T cell activation pathway and TCR signaling. The protein works closely with signaling molecules like CD3 and proteins in the MAPK pathway which together regulate gamma-delta T cell activation survival and cytokine production. Through these pathways TCR V delta 1 contributes to antitumor immunity and the maintenance of tissue homeostasis.\u003cbr\u003e\nTCR V delta 1 shows relevance in various conditions including cancer and autoimmune diseases. In some cancers like melanoma Vδ1 T cells through mechanisms related to TCR V delta 1 show potential in targeting and eliminating tumor cells. In autoimmune conditions such as celiac disease aberrant gamma-delta T cell responses can occur with TCR V delta 1 influencing the pathogenesis. Additionally interactions with proteins like NKG2D can influence these disease processes affecting how gamma-delta T cells either protect or exacerbate disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855366672553,"sku":"ab171097","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab171097","provider":"Iright","version":"1.0","type":"link"}