{"product_id":"abcam-ab172215","title":"Abcam, ab172215, Anti-SSX4 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal SSX4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SSX4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human SSX4.O60224\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSSX4 also known as Synovial Sarcoma X breakpoint 4 is a protein belonging to the SSX family of proteins. This protein has a molecular weight of approximately 22 kDa. It is typically expressed in testicular tissues but also appears in various tumors. Like other SSX proteins SSX4 contains a characteristic KRAB domain suggesting its involvement in transcriptional regulation processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of SSX4 extends to the regulation of transcription. It may act as a transcriptional repressor and participate in chromatin remodeling. SSX4 can form part of larger protein complexes influencing transcriptional activity in the cells where it is expressed. In cancer cells this protein's transcriptional regulatory role might contribute to abnormal cell growth through altered gene expression patterns.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe SSX4 protein interacts within cellular pathways associated with tumorigenesis and transcriptional regulation. It is connected to the MAPK signaling pathway impacting cellular proliferation and survival. SSX4 may have interactions with proteins in the MAPK pathway such as RAF and ERK which mediate signal transduction processes involved in cell growth and differentiation.\u003cbr\u003e\nThe abnormal expression of SSX4 is linked primarily to synovial sarcoma a type of soft tissue cancer. SSX4 when involved in translocations can create fusion proteins like SSX4-SS18 that alter normal cellular pathways leading to tumorigenesis. This protein is also investigated in contexts of other cancers potentially interacting with proteins like SSX2 through shared pathway mechanisms in cancerous growth.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852276322473,"sku":"ab172215","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab172215","provider":"Iright","version":"1.0","type":"link"}