{"product_id":"abcam-ab177149","title":"Abcam, ab177149, Anti-SFPQ antibody [EPR11847]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-SFPQ antibody [EPR11847] (ab177149) is a rabbit monoclonal antibody detecting SFPQ in  Western Blot, Flow Cytometry, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11847,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-P, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-SFPQ antibody [EPR11847] (ab177149) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of SFPQ?\u003cbr\u003e\nAnti-SFPQ [EPR11847] (ab177149) specifically detects a band for SFPQ (UniProt: P23246) at a molecular weight of 76kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-SFPQ [EPR11847] (ab177149) was first used in a scientific publication in 2013 and has been cited over 10 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR11847] also available for your convenience: ab177149, Alexa Fluor® 488 -\u003cbr\u003e\nab206742\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab246358\u003cbr\u003e\n, PE -\u003cbr\u003e\nab303128\u003cbr\u003e\n, APC -\u003cbr\u003e\nab303129\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab303130\u003cbr\u003e\n, Alkaline Phosphatase -\u003cbr\u003e\nab308758\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab310074\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab310473\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab312003\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab312479\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab321192\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSFPQ also known as splicing factor proline and glutamine-rich (PSF) is a multifunctional protein serving in various cellular processes. The protein weighs approximately 76 kDa and is ubiquitously expressed across different tissues. It mainly localizes in the nucleus where it interacts with RNA and other proteins. SFPQ plays essential roles in RNA splicing and transcription regulation among others.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSFPQ takes part in multiple cellular processes including RNA processing gene expression regulation and DNA repair. SFPQ forms complexes with other proteins such as NONO which enhances its ability in transcriptional control and RNA splicing. By binding to DNA and RNA SFPQ acts as a bridge that connects various molecular events important for cell function and survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein is actively involved in the modulation of RNA metabolic pathways and signal transduction. In particular SFPQ participates in the regulation of alternative splicing processes which can influence the diversity of the proteome. Functionally related proteins like FUS show interactions with SFPQ within these pathways jointly affecting gene expression dynamics.\u003cbr\u003e\nAberrations in SFPQ expression or function associate with neurodegenerative diseases and cancers. Mislocalization of SFPQ and its altered expression have been observed in conditions like amyotrophic lateral sclerosis (ALS) and certain leukemia types. In these disorders proteins like TDP-43 have shown associations with SFPQ contributing to the pathology through disrupted RNA processing and cellular stress responses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844099035305,"sku":"ab177149","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab177149","provider":"Iright","version":"1.0","type":"link"}