{"product_id":"abcam-ab178688","title":"Abcam, ab178688, Anti-STARD5 antibody [EPR13545(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal STARD5 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13545(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSTARD5 also known as StAR-related lipid transfer domain protein 5 is an important player in intracellular cholesterol transport. It functions as a START domain containing protein facilitating the transfer of cholesterol and other lipids between intracellular membranes. With a molecular mass of approximately 23 kDa STARD5 displays a specific pattern of expression in tissues. It is highly expressed in the liver kidney and spleen where it plays a role in cellular lipid regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe transfer of cholesterol and lipids by STARD5 helps maintain cellular lipid homeostasis. It is not known to form part of a complex but operates independently to ensure that cholesterol levels are balanced within cells. This activity supports cell membrane integrity and the synthesis of steroid hormones and bile acids. By regulating these processes STARD5 plays a significant function in maintaining cell health and metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of STARD5 is critical in the cholesterol transport and metabolism pathway. It works closely with proteins such as NPC1 and NPC2 which also facilitate cholesterol trafficking. This involvement aligns STARD5 with the lysosomal storage pathway highlighting its role in managing cholesterol storage and mobilization within cells.\u003cbr\u003e\nAltered function or expression of STARD5 links to conditions like Niemann-Pick disease type C and obesity-related dyslipidemia. Niemann-Pick disease type C is closely tied to disrupted cholesterol transport where STARD5's role intersects with NPC1 and NPC2 proteins both known for their involvement in this lysosomal disorder. In obesity-related dyslipidemia the protein's regulation of cholesterol levels can impact lipid profiles influencing disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844193374377,"sku":"ab178688","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab178688","provider":"Iright","version":"1.0","type":"link"}