{"product_id":"abcam-ab180119","title":"Abcam, ab180119, Anti-CREB3 antibody [EPR14215(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CREB3 antibody. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 10 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14215(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCREB3 also known as Cyclic AMP-responsive element-binding protein 3 is a transcription factor. It belongs to the bZIP family and features a basic-leucine zipper domain that facilitates DNA binding. This protein weighs approximately 55 kDa. CREB3 is primarily expressed in the liver and the secretory tissues where it helps in regulating various genes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCREB3 activates transcription by binding to cyclic AMP-responsive elements (CRE) in the promoters of target genes. It forms part of a wider regulatory network and can interact with other transcription factors to modulate gene expression. This protein is involved in the unfolded protein response which is essential for maintaining cellular homeostasis particularly under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nCREB3 plays an important role in the endoplasmic reticulum stress response pathway. It helps in the regulation of genes involved in protein folding and secretion. CREB3 also interacts with other proteins such as ATF6 which operates in similar pathways to coordinate cell survival and adaptation mechanisms under stress.\u003cbr\u003e\nAltered CREB3 function has been linked to metabolic disorders including liver diseases such as non-alcoholic fatty liver disease. Additionally its dysregulation may be implicated in neurodegenerative disorders potentially through interaction with proteins like GRP78 which is also involved in the unfolded protein response. These associations highlight CREB3's importance in managing stress responses and maintaining proper cellular function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855834435753,"sku":"ab180119","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab180119","provider":"Iright","version":"1.0","type":"link"}