{"product_id":"abcam-ab180325","title":"Abcam, ab180325, Recombinant Human MFAP3 protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human MFAP3 protein is a Human Fragment protein, in the 19 to 147 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P55082,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe MFAP3 protein also known as Microfibrillar-associated protein 3 is an important structural component in the matrix. It weighs approximately 31 kDa. MFAP3 is expressed mainly in connective tissues where it interacts closely with elastin and other extracellular matrix proteins. The expression of MFAP3 is significant in tissues requiring elasticity and strength like skin and blood vessels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMFAP3 contributes to the assembly and function of microfibrils. It acts as a supporting element within the extracellular matrix by aiding in the deposition and stabilization of elastin fibers. MFAP3 becomes integrated within the microfibrillar network which is important for maintaining tissue integrity and elasticity. The interactions between MFAP3 and elastin-associated proteins support extracellular matrix homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nMFAP3 interacts closely with the elastic fiber formation pathways. It plays a significant role in the assembly of elastin polymers through interactions with fibrillins and latent TGF-beta-binding proteins. Through these pathways MFAP3 works alongside other proteins such as fibrillin-1 which are important for maintaining the structure of connective tissue. These interactions help modulate the properties of tissues particularly those involved in elastic fiber-rich regions.\u003cbr\u003e\nMFAP3 shows connections to connective tissue maladies such as Marfan syndrome and cutis laxa. These conditions arise from the disruption in the structural integrity of the extracellular matrix where the protein plays a role. Changes in MFAP3 interactions particularly with proteins like fibrillin-1 in Marfan syndrome can contribute to compromised tissue integrity. Understanding MFAP3's interactions is vital for exploring potential therapeutic targets for these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844019900585,"sku":"ab180325","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab180325","provider":"Iright","version":"1.0","type":"link"}