{"product_id":"abcam-ab181083","title":"Abcam, ab181083, Anti-FRG1 antibody [EPR13098]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FRG1 antibody. Suitable for IP, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13098,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFRG1 also known as FSHD Region Gene 1 is a protein with a molecular mass of approximately 30 kDa. It is expressed in a range of human tissues with notable expression in skeletal muscle and embryonic tissues. FRG1 plays a role in cellular activities related to the maintenance and function of muscle cells. Its involvement is linked to ribonucleoprotein complex assembly and it has potential implications in cellular localization of proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFRG1 is involved in processes related to muscle development and maintenance. It is a part of the spliceosome complex which plays an important role in mRNA splicing. Through its participation in this complex FRG1 helps regulate the maturation of pre-mRNA by removing introns. These activities are essential for accurate gene expression in cells particularly in tissues requiring precise regulation like muscle fibers.\u003cbr\u003e\nPathways\u003cbr\u003e\nFour central components relate closely to FRG1's function. FRG1 is integrated into the mRNA processing and splicing pathways which are fundamental for synthesizing functional proteins. It interacts with proteins such as SMN1 which is associated with spinal muscular atrophy highlighting its connection to the ribonucleoprotein assembly pathway. Through these pathways FRG1 contributes to ensuring proper gene expression and cellular homeostasis.\u003cbr\u003e\nTwo prominent conditions involve FRG1: Facioscapulohumeral muscular dystrophy (FSHD) and certain myopathies. FSHD is associated with the abnormal expression of FRG1 leading to progressive muscle weakness. Other studies suggest FRG1 may also have interactions with DUX4 a protein implicated in FSHD pathogenesis. Understanding FRG1's role in these diseases provides insights into their molecular mechanisms supporting the development of therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844213919913,"sku":"ab181083","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab181083","provider":"Iright","version":"1.0","type":"link"}