{"product_id":"abcam-ab181801","title":"Abcam, ab181801, Anti-FBXO11 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal FBXO11 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human FBXO11.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human FBXO11. The exact immunogen used to generate this antibody is proprietary information.Q86XK2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFBXO11 also known as F-box only protein 11 is a member of the F-box protein family which are characterized by an F-box motif a sequence of approximately 40 amino acids. It has an approximate mass of 114 kDa. FBXO11 participates in the ubiquitin-proteasome system by acting as a substrate-recognition component of SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complexes. The protein is expressed in various tissues throughout the body including lung liver and skin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFBXO11 is involved in protein degradation and regulation of the cell cycle. It serves as an important component of the SCF ubiquitin ligase complex where it binds to specific substrates marking them for proteasomal degradation. FBXO11 plays an important role in cellular processes such as DNA damage response and cell growth regulation. By targeting specific proteins for degradation it regulates protein stability which is important for normal cellular proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nFBXO11 is critical in the TGF-beta signaling pathway and the apoptosis pathway. In the TGF-beta signaling pathway FBXO11 regulates the stability of inhibitory SMAD proteins like SMAD7 by targeting them for proteasomal degradation. This regulation impacts cellular responses to TGF-beta influencing processes like cell differentiation and immune responses. In apoptosis FBXO11 interacts with other proteins like BCL2 to influence cell survival and programmed cell death.\u003cbr\u003e\nFBXO11 plays a role in specific types of cancer and developmental disorders. Mutations or dysregulation of FBXO11 have identified links to diffuse large B-cell lymphoma due to its ability to affect the degradation of BCL6— a transcriptional repressor involved in the development and growth of this cancer. In developmental disorders FBXO11 mutations have associations with conditions like the oculo-facio-cardio-dental syndrome illustrating its importance in normal developmental processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860522586281,"sku":"ab181801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab181801","provider":"Iright","version":"1.0","type":"link"}