{"product_id":"abcam-ab184171","title":"Abcam, ab184171, Anti-Aldehyde dehydrogenase 10 antibody [EPR15425(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Aldehyde dehydrogenase 10 antibody. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15425(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAldehyde dehydrogenase 10 (ALDH10) functions mechanically as an enzyme that catalyzes the NAD(P)+-dependent oxidation of aldehydes to carboxylic acids. It belongs to a larger family of aldehyde dehydrogenases. Frequently used alternate names include ALDH3A2 ensuring clarification across research contexts. The mass of ALDH10 can vary slightly depending on specific isoforms and protein modifications but typically his family is around 50-55 kDa. Expression of ALDH10 mainly occurs in the liver and also in tissues including kidney and lung reflecting its roles in aldehyde metabolism across different tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAldehyde dehydrogenase 10 participates in the detoxification of aldehydes which are generated during metabolic processes. It plays an important role in protecting cells from oxidative stress by converting reactive aldehydes to less toxic carboxylic acids. ALDH10 does not seem to form part of a larger complex but acts independently to perform its function. Its enzymatic activity impacts cellular redox balance important for maintaining cellular health and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nAldehyde dehydrogenase 10 plays a significant role in the metabolic pathway processes involving amino acid and fatty acid metabolism. It is important in metabolizing aldehydes generated through lipid peroxidation and amino acid degradation pathways contributing to maintaining metabolic homeostasis. ALDH10 connects functionally with other aldehyde dehydrogenase family members like ALDH2 and ALDH3A2 which collaborate in handling various aldehyde substrates critical to these pathways.\u003cbr\u003e\nAldehyde dehydrogenase 10 holds relevance to conditions like Sjögren-Larsson syndrome and non-alcoholic fatty liver disease. ALDH3A2 a closely related protein links directly with Sjögren-Larsson syndrome due to its known genetic mutations causing reduced enzymatic function. The role of ALDH10 in modulating liver metabolism links it to non-alcoholic fatty liver disease as altered detoxification capability can lead to disease progression. Understanding these relationships helps in targeting therapies that might mitigate disease impacts by enhancing detoxification pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844266807465,"sku":"ab184171","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab184171","provider":"Iright","version":"1.0","type":"link"}