{"product_id":"abcam-ab184917","title":"Abcam, ab184917, Anti-Delta-catenin antibody [EPR17628]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Delta-catenin antibody. Suitable for WB, ICC\/IF and reacts with Mouse, Rat samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17628,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDelta-catenin also known as CTNND2 or Neurojungin is an important protein involved in cellular adhesion processes. With a molecular mass of around 122 kDa Delta-catenin is found mainly in the brain and nervous system tissues. It is a member of the armadillo\/β-catenin superfamily and plays a significant role in the structure and function of synapses connecting cytoskeletal components to cell junctions. Its expression is most prominent in neurons suggesting a function important to neuronal development and maintenance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDelta-catenin associates with and is part of the cadherin-catenin complex facilitating cell-cell adhesion in neuronal cells. This complex supports the stabilization of adherens junctions influencing cell shape signaling and gene transcription. Delta-catenin's interaction with cadherin proteins helps regulate synaptic plasticity and dendritic spine development impacting learning and memory processes within the brain.\u003cbr\u003e\nPathways\u003cbr\u003e\nDelta-catenin contributes significantly to the Wnt signaling pathway. It plays a role in cellular edge interactions and migration by modulating cadherin-mediated adhesion and Rho GTPase signaling. In collaboration with proteins such as β-catenin Delta-catenin influences processes linked to cell morphological changes and neurodevelopmental regulation. It acts as a mediator between intracellular signaling and intercellular communication impacting neurogenesis.\u003cbr\u003e\nDelta-catenin has potential links to neurodevelopmental disorders like autism spectrum disorder (ASD) and Alzheimer's disease. Alterations in Delta-catenin expression and mutations correlate with cognitive dysfunction and synaptic impairments observed in these conditions. In Alzheimer's disease Delta-catenin's interaction with β-amyloid and presenilin-1 proteins can exacerbate synaptic loss and memory deficits identifying it as a possible target in understanding disease mechanisms and therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844226306217,"sku":"ab184917","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab184917","provider":"Iright","version":"1.0","type":"link"}