{"product_id":"abcam-ab185656","title":"Abcam, ab185656, Anti-c-Myc (phospho S62) antibody [EPR17924]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-c-Myc (phospho S62) antibody [EPR17924] (ab185656) is a rabbit monoclonal antibody detecting c-Myc in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC\/IF, Dot Blot . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 40 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17924,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, IHC-P, Dot, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-c-Myc (phospho S62) antibody [EPR17924] (ab185656) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF), Dot Blot in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of c-Myc?\u003cbr\u003e\nAnti-c-Myc (phospho S62) [EPR17924] (ab185656) specifically detects a band for c-Myc (UniProt: P01106) at a molecular weight of 48kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-c-Myc (phospho S62) [EPR17924] (ab185656) was first used in a scientific publication in 2015 and has been cited over 40 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR17924] also available for your convenience: ab185656, Carrier free -\u003cbr\u003e\nab232691\u003cbr\u003e\n, PE -\u003cbr\u003e\nab305731\u003cbr\u003e\n, APC -\u003cbr\u003e\nab305732\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab305733\u003cbr\u003e\n, Alkaline Phosphatase -\u003cbr\u003e\nab308652\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab309626\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab309992\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab310355\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab311877\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab312346\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab321295\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC-Myc also known simply as Myc or MYC protein is a transcription factor with significant roles in cellular processes. Its estimated molecular weight is approximately 62 kDa. This protein is expressed in various tissues and cell types including common use in HEK (human embryonic kidney) cells for research. c-Myc functions by regulating transcription of genes involved in cell cycle progression apoptosis and cellular transformation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC-Myc is involved in regulating cell growth and proliferation. It forms part of the Myc\/Max complex which binds to DNA to regulate gene expression. This activity affects cellular metabolism ribosome biogenesis and cell cycle entry emphasizing its regulation of cellular energy and stress response. Its expression levels critically govern normal cellular functions and homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nC-Myc plays an important role in the cell cycle pathway and apoptosis regulation. Specifically c-Myc is associated with the Wnt signaling pathway which influences cellular proliferation and differentiation. It also interacts with other proteins like Cyclin D1 influencing cell cycle control. These interactions ensure c-Myc's involvement in regulating key processes related to cell proliferation and stability.\u003cbr\u003e\nC-Myc is tightly linked to cancer such as Burkitt's lymphoma and colon cancer. In these conditions c-Myc overexpression contributes to uncontrolled cell proliferation. Additionally c-Myc is associated with other oncogenic proteins like BCL2 in tumorigenesis highlighting its pivotal role in cancer development and progression. Understanding c-Myc's involvement in these diseases aids in the development of targeted therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848364413097,"sku":"ab185656","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab185656","provider":"Iright","version":"1.0","type":"link"}