{"product_id":"abcam-ab185969","title":"Abcam, ab185969, Anti-SMYD1 antibody [EPR13573]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SMYD1 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13573,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSET and MYND domain-containing protein 1 (SMYD1) also known as BOP is a protein of approximately 56 kDa that functions as a histone methyltransferase. It modifies histones by transferring methyl groups to specific lysine residues particularly histone H3 at lysine 4 (H3K4). SMYD1 expression is mainly observed in cardiac and skeletal muscle tissues. It plays a role in regulating gene expression by altering chromatin structure therefore influencing transcriptional activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSMYD1 plays a significant role in muscle differentiation and development. Its activity leads to chromatin modifications that facilitate muscle-specific gene expression. SMYD1 interacts in a complex network with other proteins involved in muscle function acting as part of the transcriptional machinery that marks certain genes for activation. This methyltransferase activity contributes to the proper formation of muscle fibers.\u003cbr\u003e\nPathways\u003cbr\u003e\nSMYD1 is important in pathways that control heart development and muscle function. It is active in the MAPK signaling pathway which is essential for cell growth and differentiation and interacts with proteins such as MEF2C a transcription factor important for muscle development. This connection influences the regulation and expression of various genes that are critical for normal cardiac and skeletal muscle function.\u003cbr\u003e\nMutations or dysregulation of SMYD1 can lead to congenital heart defects and myopathies. Its interactions with proteins like MYH7 a myosin heavy chain associated with proper cardiac muscle function are important in these conditions. Anomalies in SMYD1 activity can disrupt normal cardiac and skeletal muscle development leading to diseases characterized by structural or functional abnormalities of the heart and muscles.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850234548393,"sku":"ab185969","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab185969","provider":"Iright","version":"1.0","type":"link"}