{"product_id":"abcam-ab186431","title":"Abcam, ab186431, Anti-Mago nashi homolog 2 antibody [EPR14037-43]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Mago nashi homolog 2 antibody. Suitable for WB, ICC\/IF, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14037-43,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen shares 100% homology with both MAGOHB (UniProt Q96A72) and MAGOH (UniProt P61326). We have not performed any tests in order to determine the cross-reactivity but it is possible that ab186431 could cross-react with both MAGOHB and MAGOH. Both proteins have a similar molecular weight of 17 kDa.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Mago nashi homolog 2 often referred to as MAGOH2 is a protein with a molecular mass of approximately 18 kilodaltons. It is part of a conserved family of proteins with the notable family member being Mago nashi homolog 1 (MAGOH1). MAGOH2 is ubiquitously expressed in various tissues indicating its wide biological significance. The protein operates mainly in the cell nucleus where it forms important part of ribonucleoprotein complexes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMAGOH2 plays a significant role in RNA processing and development. It is part of the exon junction complex which influences mRNA splicing export and surveillance. This protein interacts closely with Y14 and other factors to regulate stable mRNA transport and nonsense-mediated decay. By being part of this complex MAGOH2 also aids in controlling gene expression critical for cell proliferation and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nMAGOH2 functions in the mRNA surveillance and splicing pathways. It collaborates with related proteins such as Y14 in the exon junction complex to ensure proper gene expression post-transcription. The exon junction complex affects mRNA stability and quality control which are essential for the fidelity of genetic information. These pathways highlight the importance of MAGOH2 in maintaining efficient gene expression processes.\u003cbr\u003e\nAltered function or expression of MAGOH2 can relate to developmental disorders and cancers. Abnormal exon junction complex function involving MAGOH2 and Y14 may disrupt normal RNA processing affecting normal cellular development and differentiation. The study of MAGOH2 and its interactions within the exon junction complex provides insights into congenital disorders and tumorigenesis processes. By exploring these connections researchers can better understand MAGOH2's role in health and disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850293137577,"sku":"ab186431","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab186431","provider":"Iright","version":"1.0","type":"link"}