{"product_id":"abcam-ab186866","title":"Abcam, ab186866, Anti-PPP2R4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PPP2R4 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PTPA.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human PTPA.Q15257\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPPP2R4 also known as Phosphotyrosyl Phosphatase Activator (PTPA) is an enzyme with a molecular mass of approximately 38 kDa. It functions as a regulatory subunit of the protein phosphatase 2A (PP2A) complex. PPP2R4 plays an important role in activating the phosphatase activity of PP2A by facilitating the dephosphorylation of specific phosphotyrosyl residues. It is expressed in a wide variety of tissues and is particularly abundant in the brain and heart.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe PPP2R4 protein is integral to the proper assembly and regulation of the PP2A complex. PP2A is a serine\/threonine phosphatase involved in many cellular processes including cell cycle regulation and signal transduction. PPP2R4 assists in the stabilization of this enzyme complex and maintains its catalytic activity. This regulatory function of PPP2R4 is essential for ensuring proper phosphorylation balance within the cell thereby playing a significant role in cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nPPP2R4 participates in essential cellular signaling pathways such as the MAPK\/ERK pathway and the PI3K\/AKT pathway. It interacts with various proteins within these pathways influencing cell growth proliferation and survival. PPP2R4 associates with proteins like RAF1 in the MAPK pathway to modulate the phosphorylation states that dictate pathway output. Similarly in the PI3K\/AKT pathway PPP2R4 affects downstream signaling by regulating the phosphorylation of target proteins.\u003cbr\u003e\nPPP2R4 has connections with cancer and neurodegenerative diseases. Its altered expression or dysregulation can contribute to oncogenesis due to its role in pathways controlling cell growth and apoptosis. PPP2R4 has interactions with proteins such as MYC often implicated in cancer progression. Furthermore abnormalities in its function have links to Alzheimer's disease where PPP2R4's involvement with tau protein dephosphorylation is critical. The interaction of PP2A with tau is central as improper tau phosphorylation is a feature of Alzheimer's pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854227099817,"sku":"ab186866","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab186866","provider":"Iright","version":"1.0","type":"link"}