{"product_id":"abcam-ab187649","title":"Abcam, ab187649, Anti-ZP2 antibody [EPR15467]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ZP2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15467,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZP2 also known as zona pellucida glycoprotein 2 is a structural protein critical to the protective coat surrounding oocytes called the zona pellucida. The protein is approximately 68 kDa in mass. ZP2 is highly expressed in the ovary. This glycoprotein specifically contributes to the matrix of the zona pellucida with other related proteins forming a structure that enables various reproductive events like sperm binding and prevention of polyspermy.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZP2 interacts with other zona pellucida proteins particularly ZP1 and ZP3 to form the zona pellucida matrix. This matrix allows the binding of sperm to the oocyte facilitating fertilization. The stability and integrity of this structure determine reproductive success and embryo development. ZP2 undergoes proteolytic cleavage during the fertilization process which is an important event for proper egg-sperm interaction.\u003cbr\u003e\nPathways\u003cbr\u003e\nZP2 forms an integral part of the fertilization pathway where it directly interacts with proteins ZP1 and ZP3. These proteins create a framework critical for sperm recognition and binding. Once ZP2 undergoes cleavage it assists in the progression of the acrosome reaction an important biological pathway for sperm penetration of the zona pellucida. The interactions and modifications of ZP2 within these pathways highlight the importance of precise regulation in reproduction.\u003cbr\u003e\nMutations or abnormalities in ZP2 are linked to reproductive conditions such as infertility. These changes can lead to disrupted zona pellucida integrity which affects sperm binding and fertilization ability. Additionally abnormalities in ZP2 relate to oocyte maturation defects impacting reproductive health. The protein also shows interplay with ZP3 in these conditions underlining its collaborative role in maintaining fertility.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850229239977,"sku":"ab187649","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab187649","provider":"Iright","version":"1.0","type":"link"}