{"product_id":"abcam-ab187664","title":"Abcam, ab187664, Anti-TAGAP antibody [EPR15593]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TAGAP antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15593,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTAGAP also known as T-cell activation RhoGTPase activating protein acts as a Rho GTPase-activating protein involved in the regulation of the actin cytoskeleton. It weighs approximately 70 kDa. This protein is particularly expressed in immune cells including T-cells B-cells and dendritic cells. TAGAP plays an important role in the modulation of signaling pathways essential for immune cell activation and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTAGAP contributes to the regulation of immune responses. It influences the rearrangement of the actin cytoskeleton affecting cell movement and activation. Though not a part of a large protein complex TAGAP's ability to manage cytoskeletal dynamics is critical in immune cells such as T-cells enabling proper response to antigens.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAGAP is significant in the T-cell receptor signaling and actin cytoskeleton regulation pathways. These pathways facilitate immune cell activation and migration key processes in immune response. TAGAP mediates interactions with proteins like Rac1 involved in cytoskeletal organization and Vav1 a guanine nucleotide exchange factor that activates pathways necessary for the immune response.\u003cbr\u003e\nTAGAP's function links to autoimmune diseases like multiple sclerosis and rheumatoid arthritis. Altered TAGAP expression or function can influence disease susceptibility making it a target for research. Through autoimmune-related pathways TAGAP interacts with proteins such as IL-2 and STAT4 which are implicated in these disorders highlighting its potential role in influencing immune system balance and disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850233991337,"sku":"ab187664","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab187664","provider":"Iright","version":"1.0","type":"link"}