{"product_id":"abcam-ab188320","title":"Abcam, ab188320, Anti-EMAP II\/AIMP1 antibody [EPR14168(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal EMAP II\/AIMP1 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14168(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEMAP II also known as AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1) is a protein with a mass of approximately 34 kDa. Mechanically it modulates various cellular processes including apoptosis and inflammation. This protein is expressed in several tissues with higher levels seen in the immune cells the lung and the heart. AIMP1 is part of the wider group of proteins involved in the multi-synthetase complex which ensures efficient protein synthesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAIMP1 functions beyond its role in the multi-synthetase complex to affect cellular proliferation and differentiation. It acts as a cytokine that can influence immune responses. When secreted AIMP1 shows pro-inflammatory activity targeting endothelial cells macrophages and fibroblasts. It is important for regulating the immune system's response to stress and external stimuli thereby bridging cellular activities with immune signaling networks.\u003cbr\u003e\nPathways\u003cbr\u003e\nAIMP1 integrates into both the inflammatory response pathway and apoptosis signaling. This protein interacts with TNF-alpha and IL-6 which are important players in inflammation. AIMP1's activity influences ERK and JNK pathways contributing to the regulation of apoptosis and survival of immune cells. Its relation with these pathways highlights its role as a mediator that can shift cellular balance towards survival or programmed cell death based on external cues.\u003cbr\u003e\nAIMP1 has connections to cancer and autoimmune diseases. Studies show increased levels of AIMP1 in tumors linking it to cancer progression especially in breast cancer where it interacts with proteins like p53. Furthermore AIMP1's involvement in autoimmune disorders such as rheumatoid arthritis connects it with TNF-alpha an important inflammatory mediator. This connection suggests AIMP1's function as a potential biomarker and target for therapeutic interventions in such conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850289402025,"sku":"ab188320","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab188320","provider":"Iright","version":"1.0","type":"link"}