{"product_id":"abcam-ab189315","title":"Abcam, ab189315, Anti-ACTL6A antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal ACL6A antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ACTL6A aa 200-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ACTL6A aa 200-250. The exact immunogen used to generate this antibody is proprietary information.O96019\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nACTL6A also known as BAF53A or Arp4 is a member of the actin-related protein family with a molecular mass of approximately 53 kDa. This protein plays an important role in chromatin remodeling facilitating transcriptional regulation by altering nucleosome positioning. ACTL6A shows expression in various tissues with high levels found in neurons and certain cancer cell types. Its function depends on local cellular context which influences its involvement in specific gene expression profiles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nACTL6A supports transcriptional regulation by integrating into the SWI\/SNF chromatin-remodeling complex. This complex which includes other key proteins coordinates to reposition nucleosomes aiding transcription factors in accessing target DNA sequences. ACTL6A contributes to regulation of gene expression patterns that underline cell identity and differentiation reflecting its critical role in neuronal and cancer cell biology.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe SWI\/SNF complex which includes ACTL6A integrates into pathways that control cell proliferation and differentiation. Specifically the Wnt signaling pathway uses ACTL6A to regulate gene expression necessary for proper cell function. Proteins like BRG1 and BRM serve as partners in this process helping to execute transcriptional activation. By participating in these pathways ACTL6A emphasizes its role in conserving cellular homeostasis.\u003cbr\u003e\nACTL6A exhibits associations with oncogenesis and neural disorders. Researchers observed its link to the development of glioblastoma where it influences tumor progression through interactions with other SWI\/SNF members like SMARCA4. Additionally abnormalities in ACTL6A function relate to neurodevelopmental disorders emphasizing its importance in neuronal growth and differentiation. Its connection to these diseases highlights the potential of ACTL6A as a target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854206455977,"sku":"ab189315","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab189315","provider":"Iright","version":"1.0","type":"link"}