{"product_id":"abcam-ab1903","title":"Abcam, ab1903, Anti-Alpha-synuclein antibody [4D6] - BSA and Azide free","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nAnti-Alpha-synuclein antibody [4D6] - BSA and Azide free (ab1903) is a mouse monoclonal antibody provided in a PBS only buffer for easy conjugation detecting Alpha-synuclein in  Western Blot, IHC-P . Suitable for  Human . - BSA, sodium azide, and glycerol-free for easy conjugation - Over 70 publications - Trusted since 2004\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:4D6,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human SNCA.P37840\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Alpha-synuclein antibody [4D6] - BSA and Azide free (ab1903) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples.\u003cbr\u003e\nWhat is the molecular weight of Alpha-synuclein?\u003cbr\u003e\nAnti-Alpha-synuclein [4D6] - BSA and Azide free (ab1903) specifically detects a band for Alpha-synuclein (UniProt: P37840) at a molecular weight of 16kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Alpha-synuclein [4D6] - BSA and Azide free (ab1903) was first used in a scientific publication in 2004 and has been cited over 70 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-Alpha-synuclein [4D6] - BSA and Azide free (ab1903) has over 5 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Ammonium sulfate precipitated and dialyzed tissue culture supernatant., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlpha-synuclein often referred to by alternate names such as SNCA is a protein of around 14 kDa mass. It mainly expresses in the brain particularly in presynaptic nerve terminals. This protein functions mechanically by stabilizing synaptic vesicles and maintaining synaptic function. It exists both in soluble monomer forms and as aggregates in protein filaments. Antibodies like 4D6 and EP1536Y target monomer forms of protein for more detailed studies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe alpha-synuclein protein plays critical roles in neuronal activity. It contributes to neurotransmitter release regulation by acting in the formation and plasticity of the presynaptic neuronal network. Alpha-synuclein doesn't usually form parts of large protein complexes but it may associate transiently with membranes and vesicular structures. The protein's monomer form has also been observed in alpha lines and related neuronal processes operating alongside various cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nSynaptic vesicle trafficking and dopamine neurotransmitter release are significant areas involving the alpha-synuclein protein. In these pathways alpha-synuclein interacts with other proteins like synaptophysin and protein monomer monomerizations are intrinsic to these processes. Altered function or aggregation of alpha-synuclein disrupts these pathways influencing broader neurological functions.\u003cbr\u003e\nAlterations or accumulations of alpha-synuclein are strongly linked to Parkinson's disease and Lewy body dementia. In these conditions alpha-synuclein forms abnormal protein filaments known as Lewy bodies within neurons. These formations disrupt cellular processes and neuron health. Synucleinopathies such as these show connections with proteins like parkin and DJ-1 which also have key roles in these neurodegenerative diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845039607977,"sku":"ab1903","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab1903","provider":"Iright","version":"1.0","type":"link"}