{"product_id":"abcam-ab190792","title":"Abcam, ab190792, Anti-OLF1 antibody [EPR15972]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal OLF1 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15972,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOLF1 also known as OLF-1-like protein or Olfactory neuron specific factor 1 functions mainly as a transcription factor. It weighs approximately 34 kDa and is primarily expressed in neurons and tissues related to the olfactory system. OLF1 binds specific DNA sequences to regulate the transcription of genes involved in olfactory receptor expression. It plays a critical role in the development and function of the olfactory system by influencing gene networks specific to olfactory receptors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOLF1 impacts the expression of olfactory receptor genes by interacting with other transcription factors within the nucleus. It functions as part of larger transcriptional complexes to modulate olfactory receptor gene expression. Through these activities OLF1 contributes significantly to the regulation of sensory perception in mammals. Its precise role in olfactory development and sensory neuron identity highlights its importance in neural biology.\u003cbr\u003e\nPathways\u003cbr\u003e\nOLF1 is integrated into the olfactory signaling pathway. It cooperates with proteins like O\/E-1 and O\/E-3 to regulate olfactory receptor gene clusters. This regulation is important for odor detection and signal transduction in the olfactory pathway. The olfactory signaling pathway involves multiple stages including ligand binding and signal transduction in which OLF1 contributes through its transcriptional regulatory functions.\u003cbr\u003e\nAlterations in OLF1 activity have been linked to anosmia a condition characterized by the loss of smell. Researchers also explore its involvement in neurodegenerative disorders where olfactory deficits are early symptoms such as Parkinson’s disease. Examining OLF1 interactions with proteins such as alpha-synuclein provides insights into its potential role in the pathogenesis of these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850336719017,"sku":"ab190792","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab190792","provider":"Iright","version":"1.0","type":"link"}