{"product_id":"abcam-ab190993","title":"Abcam, ab190993, Recombinant human TPM3 ALK protein","description":"\u003cp\u003eSize: 5µg \/ 10µg\u003cbr\u003e\nRecombinant human TPM3 ALK protein is a Human Fragment protein, in the 1 to 258 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;70%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;70% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activitity of ab190993 was determined to be 30 nmol\/ min\/ mg.,\u003cbr\u003e\nAccession:P06753,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nRecombinant fusion protein of TPM3 (1-258) - ALK (1058-1620) expressed in baculovirus in Sf9 insect cells using an N-terminal proprietary tag.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTPM3 ALK also known as Tropomyosin 3-Anaplastic Lymphoma Kinase is a fusion protein made by the joining of the TPM3 and ALK genes. The TPM3 part of the protein weighs about 32 kDa and it typically helps with muscle contraction while ALK is a receptor tyrosine kinase usually involved in cellular signaling and weighs approximately 162 kDa. TPM3 ALK results from a genetic rearrangement and this fusion protein is expressed in certain cancer cells particularly in some cases of anaplastic large cell lymphomas and inflammatory myofibroblastic tumors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis fusion protein acts as a constitutively active kinase meaning it remains active without normal regulation. The TPM3 ALK fusion circumvents regulatory mechanisms leading to unchecked cellular proliferation and survival. It doesn't involve participation in traditional cellular complexes but instead promotes tumorigenesis directly through its deregulated kinase activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nTPM3 ALK interacts significantly with signaling pathways that involve cell survival and proliferation. The fusion protein aberrantly activates the PI3K\/AKT pathway and the RAS\/MAPK pathway which are vital for cell growth and metabolic regulation. Through these pathways TPM3 ALK influences proteins such as STAT3 and PLCγ linking it further to the signaling network responsible for cell growth and division.\u003cbr\u003e\nThe presence of TPM3 ALK has strong links to specific types of cancer. Its expression is a marker for some anaplastic large cell lymphomas and certain inflammatory myofibroblastic tumors. The fusion between TPM3 and ALK creates a continual growth signal that parallels similar disease mechanisms seen with other ALK fusions like NPM1-ALK. This aberrant activation of ALK pathophysiology makes TPM3 ALK a potential target for therapeutic interventions aimed at inhibiting its kinase activity in affected patients.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843921170601,"sku":"ab190993","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab190993","provider":"Iright","version":"1.0","type":"link"}