{"product_id":"abcam-ab191470","title":"Abcam, ab191470, Anti-HOXA10 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nGoat Polyclonal HOXA10 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 24 publications. Immunogen corresponding to Synthetic Peptide within Human HOXA10 aa 150-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human HOXA10 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.P31260\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe homeobox protein A10 (HOXA10) also known as HOX1H is a transcription factor with important functions in gene regulation. HOXA10 has a molecular mass of approximately 38 kDa. It is part of the homeobox gene family and is expressed predominantly in the developing uterus and the hematopoietic system. This expression pattern indicates its role in development and differentiation processes particularly in these tissues where it controls several developmental genes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHOXA10 is involved in developmental regulation of gene expression. It acts as a transcription factor and binds to DNA sequences to regulate expression of target genes necessary for proper morphogenesis. HOXA10 often operates within multi-protein complexes cooperating with other proteins to exert its function efficiently. By orchestrating gene transcription HOXA10 contributes to the formation and development of certain organs and tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe regulatory role of HOXA10 is evident in the Wnt and ERK signaling pathways. These pathways involve critical development and morphogenesis functions where HOXA10 acts as a transcriptional regulator. In the Wnt pathway HOXA10 interacts with proteins like β-catenin to influence cell fate decisions. In the ERK pathway it influences cellular proliferation and differentiation processes integrating signals that contribute to organ development.\u003cbr\u003e\nHOXA10 has been associated with infertility and certain forms of leukemia. Mutations or altered expression of HOXA10 can disrupt normal uterine development leading to infertility issues. Additionally aberrations in HOXA10 expression are linked with leukemia where its interaction with proteins like MEIS1 alters cell cycle regulation and contributes to oncogenic transformation. Understanding these disease associations offers potential therapeutic targets for managing these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854461849769,"sku":"ab191470","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab191470","provider":"Iright","version":"1.0","type":"link"}