{"product_id":"abcam-ab194971","title":"Abcam, ab194971, Anti-HMGCS1 antibody - C-terminal","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal HMGCS1 antibody. C-terminal. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human HMGCS1 aa 450 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human HMGCS1 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q01581\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe HMGCS1 protein also known as 3-hydroxy-3-methylglutaryl-CoA synthase 1 functions as an enzyme with an approximate molecular weight of 57 kDa. This enzyme catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA to form HMG-CoA a critical step in the mevalonate pathway. HMGCS1 is expressed in various tissues with high levels detected in the liver. It plays a role in cholesterol biosynthesis reflecting its importance in metabolic processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme contributes to the synthesis of cholesterol and other isoprenoids. HMGCS1 is not typically part of a multi-protein complex but operates downstream of acetyl-CoA in the mevalonate pathway. Its activity helps maintain cellular homeostasis by regulating the pool of HMG-CoA an important precursor in cholesterol and ketone bodies synthesis. The modulation of HMGCS1 activity impacts cellular proliferation and growth given the pathway's connection to sterol and non-sterol isoprenoid production.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe enzyme participates chiefly in the mevalonate and cholesterol biosynthesis pathways. It functions alongside HMG-CoA reductase (HMGCR) which converts HMG-CoA to mevalonate further linking to cholesterol synthesis and regulatory pathways. The interrelation of HMGCS1 with other enzymes like HMGCR highlights its significance in lipid metabolism and cellular energy balance influencing pathways essential for cell membrane synthesis and signaling molecules production.\u003cbr\u003e\nAlterations in HMGCS1 expression or function can associate with dyslipidemia and cardiovascular disease. Elevated levels of cholesterol due to disruptions in the mevalonate pathway implicate HMGCS1 in these disorders. Moreover mutations or heterogeneity in HMGCS1 activity may connect with metabolic syndrome where the pathways involving cholesterol biosynthesis play a role. Additionally understanding interactions with proteins such as HMGCR could provide insights into therapeutic targets for hypercholesterolemia and related cardiovascular conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853984092329,"sku":"ab194971","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab194971","provider":"Iright","version":"1.0","type":"link"}