{"product_id":"abcam-ab195303","title":"Abcam, ab195303, Alexa Fluor® 647 Anti-GM130 antibody [EP892Y] - cis-Golgi Marker","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nAnti-GM130 antibody [EP892Y] - cis-Golgi Marker - Alexa Fluor® 647 conjugated (ab195303) is a rabbit recombinant monoclonal antibody detecting GM130 in  Flow Cytometry (Intra), Flow Cytometry, ICC\/IF . Suitable for  Human . - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP892Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:Alexa Fluor® 647,\u003cbr\u003e\nExcitation\/Emission:Ex: 650nm, Em: 665nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAlexa Fluor® 647 Anti-GM130 antibody [EP892Y] - cis-Golgi Marker (ab195303) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human samples.\u003cbr\u003e\nRelated products\u003cbr\u003e\nAntibody clone EP892Y is also available pre-conjugated to a variety of labels for your convenience – Anti-GM130 Alexa Fluor® 647 [EP892Y] - cis-Golgi Marker (ab195303).\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EP892Y] also available for your convenience:\u003cbr\u003e\nab52649\u003cbr\u003e\n, Alexa Fluor® 647 - ab195303, Carrier free -\u003cbr\u003e\nab215966\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab275987\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab277236\u003cbr\u003e\nab302489\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab302490\u003cbr\u003e\n, PE -\u003cbr\u003e\nab303011\u003cbr\u003e\n, APC -\u003cbr\u003e\nab303012\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab303013\u003cbr\u003e\n, Alkaline Phosphatase -\u003cbr\u003e\nab308664\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab311890\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab312361\u003cbr\u003e\n, Alexa Fluor® 750 -\u003cbr\u003e\nab321664\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nAlexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGM130 also known as Golgi matrix protein 130 kDa or GM-130 plays an important role in the organization of the Golgi apparatus. The GM130 protein is vital for maintaining the structure of the Golgi serving as a Golgi marker for researchers. Its molecular weight is approximately 130 kDa. You will commonly find GM130 expressed in cells localizing to the cis-Golgi network. As a Golgi marker it serves as an indication of the integrity and positioning of the Golgi apparatus in the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGM130 serves as a structural component within the Golgi matrix. It interacts with other proteins such as GRASP65 to form a complex which is essential for Golgi stacking and maintenance of Golgi architecture. This interaction helps regulate transport processes inside cells. GM130 proteins help formation of mini-stacks and transitioning of vesicles. In cells GM130 plays a significant role to maintain efficient protein trafficking through the Golgi network.\u003cbr\u003e\nPathways\u003cbr\u003e\nGM130 interacts with proteins like Rab1 during the vesicular transport pathway. It plays a part in the transport of proteins from the endoplasmic reticulum to the Golgi apparatus. Another related pathway involves SNARE proteins whereby GM130 contributes to membrane docking and fusion events. Through these interactions GM130 modulates the fidelity and specificity of molecular cargo transport within the cell.\u003cbr\u003e\nGM130 has a connection to neurodegenerative diseases such as frontotemporal dementia. Disruption in GM130 proteins affects Golgi structure and function potentially leading to protein trafficking defects associated with the disorder. GM130 also relates to Alzheimer's disease through its interaction with tau protein. Alterations in GM130's function can influence tau pathology contributing to disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844233711785,"sku":"ab195303","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab195303","provider":"Iright","version":"1.0","type":"link"}