{"product_id":"abcam-ab196025","title":"Abcam, ab196025, Anti-KRIT1 antibody [EPR16560]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal KRIT1 antibody. Suitable for WB, ICC\/IF and reacts with Mouse, Human samples. Cited in 11 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16560,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKRIT1 also known as Krev interaction trapped 1 and CCM1 is a protein encoded by the KRIT1 gene. This protein has a mass of approximately 99 kilodaltons. Mechanically KRIT1 functions as an adapter protein interacting with several molecular partners to regulate cellular processes. KRIT1 is expressed broadly in various tissues including in the endothelial cells of blood vessels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein is involved in the maintenance of vascular integrity and formation. It forms a complex with other proteins like CCM2 and PDCD10 playing a critical role in stabilizing cell-cell junctions. By organizing junctional proteins KRIT1 supports cellular architecture and mechanotransduction. This action ensures proper response to hemodynamic forces within blood vessels.\u003cbr\u003e\nPathways\u003cbr\u003e\nKRIT1 is involved in the RhoA signaling pathway and integrin-dependent pathways. In the RhoA signaling pathway KRIT1 interacts with HEG1 and MAPK to facilitate signal transduction that influences cell shape and movement. Through the integrin-dependent pathway KRIT1 regulates integrins essential for cell adhesion and migration. This regulation highlights its role in mechanotransduction and vascular stability.\u003cbr\u003e\nKRIT1 mutations associate with cerebral cavernous malformations (CCM) a condition characterized by vascular lesions in the brain. These mutations disrupt interactions with CCM2 affecting vascular development and stability. KRIT1 has connections to other cerebrovascular-related proteins indicating its involvement in leaky blood vessels that form lesions. Understanding KRIT1's interaction pathways is key to developing therapies for CCM and potentially related vascular disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844145434793,"sku":"ab196025","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab196025","provider":"Iright","version":"1.0","type":"link"}