{"product_id":"abcam-ab197017","title":"Abcam, ab197017, Anti-ETAA1 antibody [EPR14052(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ETAA1 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14052(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nETAA1 also known as Ewing tumor-associated antigen 1 is a protein recognized for its role in DNA replication stress response. It is approximately 92 kDa in mass and ubiquitously expressed in various human tissues. ETAA1 functions at the mechanical level by activating the ATR (ataxia telangiectasia and Rad3-related) kinase an enzyme critical for maintaining genomic stability. This protein contains ATR activators that allow the phosphorylation of various substrates participating in DNA damage repair.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nETAA1 plays a significant role in the cellular response to replication stress ensuring accurate DNA replication and repair. It does not function as a single entity but acts as part of the ATR activation complex which is involved in sensing and signaling DNA damage. By facilitating ATR activation ETAA1 helps coordinate cell cycle checkpoints and repair processes maintaining genomic integrity under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nETAA1 integrates into the DNA damage response pathway and cellular cycle regulation. It operates closely with ATR within the DDR (DNA Damage Response) pathway sharing functional interactions with proteins like TopBP1 and Rad17 which also contribute to ATR activation. Together these proteins ensure the monitoring and repairing of DNA lesions therefore preventing the accumulation of mutations.\u003cbr\u003e\nETAA1 associates with cancer and developmental disorders linked to genomic instability. Its dysfunction or altered expression can disrupt the DNA damage response potentially leading to the accumulation of mutations seen in different cancers. The interaction of ETAA1 with ATR emphasizes this relationship as both proteins become pivotal in responding to DNA damage and maintaining cellular health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850333900969,"sku":"ab197017","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab197017","provider":"Iright","version":"1.0","type":"link"}