{"product_id":"abcam-ab197727","title":"Abcam, ab197727, Alexa Fluor® 488 Anti-Endothelial Cell antibody [RECA-1]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal Endothelial Cell antibody - conjugated to Alexa Fluor® 488. Suitable for IHC-Fr and reacts with Rat samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RECA-1,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nConjugation:Alexa Fluor® 488,\u003cbr\u003e\nExcitation\/Emission:Ex: 495nm, Em: 519nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat,\u003cbr\u003e\nApplications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAlexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Stable for 12 months at -20°C, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEndothelial cells sometimes referred to as endothelium form the thin layer of approximately 1-2 µm thickness that lines the interior surface of blood vessels and lymphatic vessels. They possess a considerable array of roles mainly being a barrier between the vessel lumen and surrounding tissue and they regulate the passage of materials and the transit of white blood cells into and out of the bloodstream. Endothelial cells are widespread found in veins arteries capillaries and the heart. These cells express a variety of markers used to identify them and antibodies targeting endothelial markers are valuable tools in research and diagnostics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEndothelial cells maintain vascular tone and blood fluidity and they mediate angiogenesis which is the development of new blood vessels from pre-existing ones. They achieve these functions through the expression of adhesion molecules and growth factors. Endothelial cells contribute to the formation of a selective permeability barrier and respond to mechanical and chemical signals. They do not function alone; they are part of a larger vascular complex that includes smooth muscle cells and pericytes.\u003cbr\u003e\nPathways\u003cbr\u003e\nEndothelial cells play key roles in the nitric oxide (NO) signaling and angiogenesis pathways. They produce nitric oxide a critical molecule for vasodilation and blood pressure regulation through the action of enzymes like endothelial nitric oxide synthase (eNOS). In the angiogenesis pathway endothelial cells interact with proteins like vascular endothelial growth factor (VEGF) which signals the proliferation and migration processes necessary for new blood vessel formation.\u003cbr\u003e\nEndothelial dysfunction links to cardiovascular conditions like atherosclerosis and hypertension. Damage or alteration in endothelial cell function can lead to abnormal vascular behavior. Oxidative stress and inflammation often disrupt endothelial activity involving proteins such as E-selectin and intercellular adhesion molecule-1 (ICAM-1) contributing to disease progression. Understanding these associations highlights the importance of endothelial cell studies in addressing cardiovascular disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860547326121,"sku":"ab197727","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab197727","provider":"Iright","version":"1.0","type":"link"}