{"product_id":"abcam-ab197894","title":"Abcam, ab197894, Anti-Tin2 antibody [EPR15319]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Tin2 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 10 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15319,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTIN2 also known as TERF1-interacting nuclear factor 2 is a pivotal protein involved in telomere maintenance. It has a molecular mass of approximately 50 kDa. This protein is expressed in the nucleus where it plays an integral role in structuring chromosome ends. TIN2 specifically associates with telomeric regions to regulate their length and integrity. It forms connections with other proteins to facilitate its function in telomers' structural configuration.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTIN2 integrates into the shelterin complex a group of six proteins that protect telomeres from being recognized as DNA damage. It acts as a stabilizer within this complex and helps maintain telomere integrity. In doing so TIN2 modulates the actions of telomerase and other telomere-binding proteins to ensure proper chromosome end function. This responsibility makes it essential for preventing excessive telomere shortening which can lead to genomic instability.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of TIN2 is significant in telomere length regulation and DNA damage response mechanisms. TIN2 operates within these pathways to manage telomerase activity and interaction with telomere ends. It collaborates with other shelterin proteins like TRF1 and TRF2 which also participate in maintaining telomere function. TIN2's role in these pathways highlights its contribution to chromosome end protection and preventive response against DNA damage.\u003cbr\u003e\nTIN2 dysfunction is linked to conditions like dyskeratosis congenita and aplastic anemia. These disorders are marked by defective telomere maintenance leading to progressive bone marrow failure and other cellular deficiencies. Mutations in TIN2 can perturb the function of shelterin proteins including TRF1 contributing to the compromised telomere integrity seen in these diseases. Understanding TIN2's role offers insights into therapeutic targets for managing telomere-associated disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855841087657,"sku":"ab197894","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab197894","provider":"Iright","version":"1.0","type":"link"}