{"product_id":"abcam-ab199430","title":"Abcam, ab199430, Anti-C4 binding protein\/C4BPB antibody [EPR17101]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal C4 binding protein\/C4BPB antibody. Suitable for IP, WB, ICC\/IF, IHC-P and reacts with Human, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17101,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:IP, IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC4 binding protein also known as C4BPB is a vital component of the complement system responsible for immune function. It has a molecular mass of approximately 570 kDa and is expressed mainly in liver tissues. C4BPB is a multi-chain protein complex consisting of several alpha and beta chains. This structure allows it to perform important roles in the regulation of immune responses. The presence of C4BPB can be detected in the serum where it acts to modulate the activity of complement C4 protein.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC4 binding protein plays a defensive role in the immune system by regulating complement activation. It is part of a larger complex that controls the complement pathway which is integral to immune surveillance and removing pathogens. C4BPB functions primarily by binding to complement C4 preventing the formation of the C3 convertase which is an enzyme that amplifies the complement response. This binding action helps in stabilizing the protein C4 and complement C4 serum to avoid unnecessary immune reactions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe complement system pathway prominently features C4 binding protein. In the classical complement activation pathway C4BPB works closely with other proteins such as C3 and C4 to ensure regulatory balance. Its inhibitory action on the complement C4 pathway provides a safeguard against damage to host tissues during immune responses. The interplay between C4BPB and protein C4 offers a protective mechanism reducing excessive inflammation which can lead to tissue injury.\u003cbr\u003e\nC4 binding protein holds relevance in conditions like rheumatoid arthritis and systemic lupus erythematosus (SLE). Both diseases involve dysregulation of the immune system where inappropriate complement activation occurs. C4BPB's ability to inhibit complement C4 activation suggests that disruptions in its function may contribute to the pathophysiology of these autoimmune disorders. Additionally the relationship between C4BPB and other complement proteins like C3 and C4 is critical in understanding the underlying mechanisms driving these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850358706345,"sku":"ab199430","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab199430","provider":"Iright","version":"1.0","type":"link"}