{"product_id":"abcam-ab199850","title":"Abcam, ab199850, Anti-THUMPD1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal THUMPD1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human THUMPD1 aa 300 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human THUMPD1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NXG2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTHUMPD1 also known as THUMP domain-containing protein 1 is a protein involved in RNA modification processes. The protein has a molecular mass of approximately 45 kDa. THUMPD1 expresses in various tissues with notable levels in the brain liver and testis. As an essential protein it plays a mechanical role in RNA processing and modification specifically within transfer RNAs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTHUMPD1 is involved in the methylation of RNA molecules. It often functions as part of a larger protein complex collaborating with other proteins for accurate RNA modification. These modifications affect RNA stability and translation critical for regular cellular function. This active participation in RNA systems indicates a significant impact on maintaining protein homeostasis within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nTHUMPD1 has a role in important RNA-centric pathways. It connects with the tRNA methylation pathway and is associated closely with the RNA processing pathway. Proteins like TRMT1 and NOP2 relate to THUMPD1 within these pathways sharing the common function of ensuring correct RNA modifications. This connectivity positions THUMPD1 as a significant participant in genetic regulation activities.\u003cbr\u003e\nTHUMPD1 links to several genetic conditions with defects in RNA modification pathways. Research highlights connections to specific cancers such as liver cancer where dysregulation of RNA methylation is observed. Additionally THUMPD1 may influence neurological disorders through related pathways. Interactions with proteins such as METTL3 further suggest its involvement in these conditions where changes in RNA processing are a factor.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853992546473,"sku":"ab199850","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab199850","provider":"Iright","version":"1.0","type":"link"}