{"product_id":"abcam-ab201046","title":"Abcam, ab201046, Anti-HCE antibody [EPR19384]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HCE antibody. Suitable for IP, WB, ICC\/IF, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19384,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IP, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHCE also known as Heat Shock Cognate 70 is a stress-responsive protein with a mass of approximately 70 kDa. This protein plays a mechanical role as a molecular chaperone assisting in the proper folding of nascent polypeptides and the refolding of misfolded proteins. HCE expression occurs in various tissues but notably it is abundant in the cytoplasm of cells exposed to stressful conditions like heat shock. The protein assists in maintaining cellular protein homeostasis particularly during periods of increased environmental stress.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHCE contributes to multiple cellular processes critical for survival and adaptation. It is an important component of the chaperone complex and interacts with co-chaperones to facilitate protein folding and prevent aggregation. HCE enhances cellular resilience by stabilizing proteins and protecting against cellular stress-induced damage. Additionally it supports proteostasis by targeting misfolded proteins for degradation via the ubiquitin-proteasome system.\u003cbr\u003e\nPathways\u003cbr\u003e\nHCE is involved in essential cellular mechanisms beyond protein folding including the unfolded protein response (UPR) and heat shock response (HSR). In these pathways HCE collaborates with proteins like HSP40 and HSP90 to restore normal protein conformation and function. The heat shock response pathway is a protective cellular mechanism that activates a cascade to manage stress-related protein damage and ensure cell survival during acute stress.\u003cbr\u003e\nHCE has significant connections to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Research indicates that aberrant HCE function may contribute to protein aggregation a hallmark of these conditions. In Alzheimer’s disease HCE interacts with proteins like tau and amyloid precursor protein (APP) influencing pathological aggregation processes. Understanding the role of HCE in these disorders opens potential avenues for therapeutic targeting to mitigate protein aggregation and fibrous plaques characteristic of neurodegeneration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844169912489,"sku":"ab201046","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab201046","provider":"Iright","version":"1.0","type":"link"}