{"product_id":"abcam-ab201212","title":"Abcam, ab201212, Anti-RNF146 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal RNF146 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human E3 ubiquitin-protein ligase RNF146 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human E3 ubiquitin-protein ligase RNF146 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9NTX7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRNF146 also known as Iduna or dactylidin is an E3 ubiquitin ligase with a molecular mass of approximately 33 kDa. It plays an important role in the poly(ADP-ribose) (PAR)-dependent ubiquitination process adding ubiquitin to target proteins for degradation. RNF146 binds to PAR chains using its WWE domain triggering the ubiquitin-proteasome pathway. This protein is widely expressed in tissues notably in the brain heart and testis indicating its involvement in various cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRNF146 exhibits significant functions that influence cell survival and DNA repair. It interacts with PARP1 an important protein in the DNA damage response. As part of a larger protein complex RNF146 identifies and ubiquitinates proteins modified by PAR facilitating their recognition and subsequent degradation by the proteasome. Through these interactions RNF146 controls levels of damaged proteins and modulates the cellular response to stress contributing to genomic stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nRNF146 plays a part in the Wnt\/β-catenin signaling pathway and the DNA damage response pathway. Within the Wnt signaling pathway RNF146 regulates Axin1 and other components influencing cell proliferation and differentiation. Additionally in the DNA damage pathway RNF146 aids in the fine-tuning of protein levels necessary for efficient repair by controlling PAR-modified proteins. Its interactions with proteins such as PARP1 and Tankyrase position RNF146 as a significant player in these pathways.\u003cbr\u003e\nRNF146 has connections to neurodegenerative diseases and cancer. Abnormal RNF146 expression or activity can disrupt cellular homeostasis contributing to the pathogenesis of Alzheimer's disease through interactions with proteins like Tankyrase. In cancer altered RNF146 activity can influence tumorigenesis by modulating key signaling pathways such as the Wnt\/β-catenin pathway. These links suggest that targeting RNF146 could offer therapeutic potential for both neurodegenerative diseases and cancer.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854359056553,"sku":"ab201212","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab201212","provider":"Iright","version":"1.0","type":"link"}