{"product_id":"abcam-ab202027","title":"Abcam, ab202027, Anti-Glutaminase C antibody [EPR19525]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Glutaminase antibody. Suitable for IP, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 6 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19525,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), IP, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutaminase C also known as kidney-type glutaminase or GLS2 is an enzyme with a high molecular mass of approximately 65 kDa. This enzyme belongs to the mitochondrial compartment and carries out the conversion of glutamine to glutamate releasing ammonia in the process. It is expressed in various tissues including brain kidney and liver where it plays an important role in cellular metabolism. The enzyme demonstrates increased expression levels under specific conditions where cellular proliferation and energy requirements are high.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGlutaminase C acts as an important player in nitrogen metabolism and cellular bioenergetics. It functions within the mitochondria facilitating the glutaminolysis pathway which provides intermediates for the tricarboxylic acid (TCA) cycle. Although glutaminase C mainly acts as a monomer in certain conditions it might participate in multiprotein complexes that aid its regulation and activity. This regulatory mechanism plays a vital role in energy homeostasis and cellular growth demands.\u003cbr\u003e\nPathways\u003cbr\u003e\nGlutaminase C is involved in the glutaminolysis and TCA cycle pathways contributing significantly to energy production and biosynthesis in proliferating cells. It works in concert with related proteins like glutamate dehydrogenase which further converts the produced glutamate into α-ketoglutarate feeding into the TCA cycle. These combined actions support cellular adaptations during increased metabolic demand especially in cancerous cells where metabolic shifts are noticeable.\u003cbr\u003e\nGlutaminase C has a strong connection to cancer and neurological disorders. Cancer cells frequently exhibit heightened glutaminase C activity to sustain rapid growth associating with proteins such as c-Myc that drive metabolic reprogramming. Additionally in neurological ailments like epilepsy dysregulation of glutaminase C may alter neurotransmitter levels disturbing normal synaptic function. The enzyme's activity links to proteins involved in neuronal signaling suggesting its influence extends beyond mere metabolic processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855869563049,"sku":"ab202027","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab202027","provider":"Iright","version":"1.0","type":"link"}