{"product_id":"abcam-ab202898","title":"Abcam, ab202898, Anti-ZWILCH antibody [EPR18035-28]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ZWILCH antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18035-28,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZWILCH also known as ZW10 interactor-like or ZWILCH kinetochore protein is an important component in cell division especially during mitosis. The protein has a molecular mass of approximately 85 kDa. ZWILCH is highly expressed in dividing cells with enrichment in tissues that have high mitotic rates like the bone marrow and germinal centers. Functionally ZWILCH is a component of the RZZ complex comprising ROD (also known as KNTC1) and ZW10 helping in the proper attachment of chromosomes at the kinetochores.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZWILCH is fundamental in ensuring accurate chromosome alignment and segregation during cell division. It plays a part as a component of the RZZ complex. The RZZ complex localizes to kinetochores which are critical for connecting spindle microtubules to chromosomes promoting bioriented chromosome alignment. Moreover ZWILCH contributes to the spindle assembly checkpoint a safety mechanism that prevents chromosome mis-segregation by delaying progress to anaphase until all chromosomes are correctly attached.\u003cbr\u003e\nPathways\u003cbr\u003e\nZWILCH plays integral roles in the mitotic spindle checkpoint and chromosomal stability pathways. Within these pathways ZWILCH associates closely with spindle assembly checkpoint proteins such as MAD2 and BUBR1 which monitor kinetochore-microtubule attachment. ZWILCH through its role in the RZZ complex communicates tension status between sister chromatids ensuring proper cell-cycle progression and genomic integrity.\u003cbr\u003e\nZWILCH has significant connections to both cancer and aneuploidy. Misregulation or mutations in ZWILCH can result in chromosomal instability a main feature in various cancers. Aberrant activity of the RZZ complex where ZWILCH is vital could disrupt normal cell division and cause aneuploidy a condition characterized by an abnormal number of chromosomes seen in numerous cancer types and genetic disorders. Therefore ZWILCH and its associations with proteins like ZW10 and ROD serve as potential biomarkers for chromosomal instability-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850297495721,"sku":"ab202898","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab202898","provider":"Iright","version":"1.0","type":"link"}