{"product_id":"abcam-ab203571","title":"Abcam, ab203571, Anti-Survivin 3 alpha antibody [9H18L32]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Recombinant Monoclonal BIRC5 antibody. Suitable for ICC, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BIRC5.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:9H18L32,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human BIRC5.O15392\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSurvivin 3 alpha also known as BIRC5 isoform 3 or survivin-ΔEx3 is a protein that plays a role in inhibiting apoptosis and regulating cell division. It has a molecular mass of approximately 18 kDa. This protein is expressed in various tissues but it is notably higher in cancer cells. Survivin 3 alpha is distinct in its function from the full-length survivin isoform due to its unique splice variant form which influences its mechanical role in cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis splice variant contributes to cell cycle regulation and apoptosis inhibition. Although not extensively part of larger complexes Survivin 3 alpha can interact with microtubules during cell division assisting in the proper chromosome alignment and segregation. This activity is important for the stability and survival of rapidly dividing cells providing these cells with an adaptive advantage under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nSurvivin 3 alpha is involved in the inhibition of the apoptotic pathway and the regulation of the mitotic spindle apparatus. It interacts with important molecular players such as caspases which are pivotal in apoptosis and Aurora B kinase which is significant in regulating mitotic phase activities. Through these interactions Survivin 3 alpha modulates cell survival and mitotic processes contributing to the fine balance of cell proliferation and death.\u003cbr\u003e\nSurvivin 3 alpha expression levels are associated with cancer progression and treatment resistance. Elevated levels are commonly seen in various cancers including lung and colon cancers linking it to the same pathway network as full-length Survivin and other inhibitor of apoptosis proteins (IAPs). As a result Survivin 3 alpha participates in the mechanisms contributing to tumor survival and growth making it a target of interest for cancer therapeutics development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850324431017,"sku":"ab203571","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab203571","provider":"Iright","version":"1.0","type":"link"}