{"product_id":"abcam-ab204075","title":"Abcam, ab204075, Anti-OBSL1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal OBSL1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human OBSL1 aa 1250-1400.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human OBSL1 aa 1250-1400. The exact immunogen used to generate this antibody is proprietary information.O75147\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe target OBSL1 also known as Obscurin-like 1 is a protein mechanically involved in the cellular architecture. It possesses a mass of approximately 189 kDa. OBSL1 is known for its expression in various tissues notably in muscle and heart. It helps maintain structural integrity by interacting with cytoskeletal proteins. This protein features multiple domains that enable its structural functions and protein-protein interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of Obscurin-like 1 extends to maintaining cytoskeletal stability. It is involved in muscle and skeletal systems contributing to the organization of myofibrils. OBSL1 functions as part of a protein complex that helps connect the contractile apparatus to the sarcolemma. It interacts extensively with other cytoskeletal elements coordinating the proper alignment and spacing of muscle fibers which is important for muscle function.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe interactions involving Obscurin-like 1 pertain to the signaling mechanisms that regulate muscle development and repair. The protein participates in pathways such as the integrin signaling pathway and the regulation of the cytoskeleton. It shows association with proteins like titin and ankyrin playing a critical role in the assembly and maintenance of muscle cells. These interactions facilitate cellular response to mechanical stress and help organize sarcomeres.\u003cbr\u003e\nResearch links Obscurin-like 1 with muscular disorders and growth deficiencies. Mutations or dysregulation in OBSL1 have connections to conditions like 3M syndrome which affects growth hormone signaling pathways and results in growth retardation. The protein associates with CUL7 which is involved in ubiquitination processes. Alterations in OBSL1 can disrupt normal cellular function highlighting its importance in health and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850146795689,"sku":"ab204075","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab204075","provider":"Iright","version":"1.0","type":"link"}