{"product_id":"abcam-ab204757","title":"Abcam, ab204757, Anti-G gamma12 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal G gamma12 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-12 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-12 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9UBI6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe G gamma12 protein also known as guanine nucleotide-binding protein subunit gamma 12 is a component of the heterotrimeric G proteins. It has an approximate molecular mass of 8 kDa. This protein predominantly resides at the plasma membrane where it partners with its associated G alpha and G beta subunits. G gamma12 shows expression in various tissues including the brain and heart where it functions as an integral part of signal transduction processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nG gamma12 is involved in transmitting signals within cells by interacting with its G alpha and G beta counterparts to form a functional G protein complex. This complex plays a critical role in modulating and transducing signals from activated cell surface receptors to downstream effectors. As a member of the G protein gamma subunit family G gamma12 aids in diverse cellular responses such as cell growth differentiation and motility.\u003cbr\u003e\nPathways\u003cbr\u003e\nG gamma12 plays a part in the MAPK signaling pathway and the PI3K-Akt signaling pathway. These pathways are significant for regulating various cellular activities like survival and metabolism. Proteins like G beta and specific G alpha subunits closely interact with G gamma12 in these pathways influencing the downstream signaling cascades and cellular responses.\u003cbr\u003e\nG gamma12 has associations with cancer and cardiovascular diseases. In the context of cancer altered G gamma12 expression affects cell proliferation and migration thereby contributing to tumor development. In cardiovascular diseases it implicates processes such as heart rate regulation. Through these conditions G gamma12 connects to other proteins like G alpha q and beta-adrenergic receptors contributing to the disease state's pathophysiology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854197313705,"sku":"ab204757","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab204757","provider":"Iright","version":"1.0","type":"link"}