{"product_id":"abcam-ab209962","title":"Abcam, ab209962, PE Anti-PD-L1 antibody [28-8]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nAnti-PD-L1 antibody [28-8] - PE conjugated (ab209962) is a rabbit recombinant monoclonal antibody detecting PD-L1 in  Flow Cytometry . Suitable for  Human . - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:28-8,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:PE,\u003cbr\u003e\nExcitation\/Emission:Ex: 480;565nm, Em: 578nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nPE Anti-PD-L1 antibody [28-8] (ab209962) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt) in Human samples.\u003cbr\u003e\nRelated products\u003cbr\u003e\nAntibody clone 28-8 is also available pre-conjugated to a variety of labels for your convenience – Anti-PD-L1 PE [28-8] (ab209962).\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [28-8] also available for your convenience:\u003cbr\u003e\nab205921\u003cbr\u003e\n, APC -\u003cbr\u003e\nab206967\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab209889\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab209959\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab209960\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab209961\u003cbr\u003e\n, PE - ab209962, Alexa Fluor® 555 -\u003cbr\u003e\nab213358\u003cbr\u003e\n, Alexa Fluor® 568 -\u003cbr\u003e\nab213359\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab213360\u003cbr\u003e\n, FITC -\u003cbr\u003e\nab224027\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab228413\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab278010\u003cbr\u003e\n, Alexa Fluor® 647 - ab303724, Carrier free - ab307495, Biotin -\u003cbr\u003e\nab322788\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Do Not Freeze, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPD-L1 also known as Programmed Death-Ligand 1 or CD274 is a protein involved in immune modulation. Mechanically PD-L1 interacts with its receptors particularly PD-1 to regulate cellular immune responses. This transmembrane protein has a calculated molecular weight of approximately 33 kDa. PD-L1 is expressed on various cell types including tumor cells and immune cells such as dendritic cells macrophages and B cells. Its expression is often upregulated in response to inflammatory cytokines.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPD-L1 plays a central role in immune evasion mechanisms utilized by tumors. It is not part of a larger protein complex but directly interacts with PD-1 and CD80. When PD-L1 binds to PD-1 it sends inhibitory signals leading to decreased T cell activation and proliferation allowing cancer cells to avoid immune destruction. PD-L1 expression provides a mechanism for tumors to suppress immune surveillance facilitating tumor progression.\u003cbr\u003e\nPathways\u003cbr\u003e\nPD-L1 is integral to the immune checkpoint pathway which is an important regulator of immune response. The interaction between PD-L1 and PD-1 provides a mechanism for immune tolerance which is part of the broader adaptive immune system pathway. PD-L1 is related to other immune checkpoint proteins such as CTLA-4 in its function to limit autoreactivity and promote immune homeostasis.\u003cbr\u003e\nPD-L1 is most associated with cancer particularly in tumors such as melanoma and non-small cell lung cancer. PD-L1 expression on tumor cells often correlates with poor prognosis. PD-L1 directly interacts with PD-1 in these cancers a target for immunotherapies such as checkpoint inhibitors which aim to block this interaction and restore immune activity against tumors. PD-L1 involvement extends to autoimmune disorders where altered expression can impact tolerance and lead to immune-related tissue damage.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852559700137,"sku":"ab209962","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab209962","provider":"Iright","version":"1.0","type":"link"}