{"product_id":"abcam-ab211297","title":"Abcam, ab211297, Anti-Ten-1 antibody - N-terminal","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal Ten-1 antibody. N-terminal. Suitable for IHC-P, ICC\/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TENM1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TENM1. The exact immunogen used to generate this antibody is proprietary information.Q9UKZ4,\u003cbr\u003e\nSpecificity:ab211297 is predicted to not cross-react with other members of the ODZ family.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTen-1 also known as Tensin-1 is a cytoskeletal protein with a mass of around 220 kDa. This protein mainly localizes to focal adhesions structures that connect the extracellular matrix to the cytoskeleton. Ten-1 binds actin filaments and it contains several domains such as a SH2 domain enabling it to interact with phosphotyrosine residues. This protein is expressed in various tissues with higher levels in kidney liver and heart where it plays a part in maintaining cellular architecture and signal transduction.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTen-1 functions in cell adhesion and migration by linking the cytoskeleton to integrins at focal adhesions. Sometimes Ten-1 forms complexes with other cytoskeletal proteins helping stabilize cell-extracellular matrix interactions. These complexes are essential for mechanical signal transduction and cellular responses to external stimuli. Expression and regulation of Ten-1 influence cell motility and structural integrity playing roles in tissue morphogenesis and wound healing.\u003cbr\u003e\nPathways\u003cbr\u003e\nTen-1 significantly impacts the Rho signaling pathway influencing cell shape and motility. It does this through interactions with proteins such as Ras-related C3 botulinum toxin substrate 1 (Rac1) and Rho GTPases modulating actin filament dynamics. Another relevant pathway is the focal adhesion kinase (FAK) pathway where Ten-1 interacts with FAK affecting signaling cascades that regulate cell movement and survival. These pathways show how Ten-1 participates in processes important for cellular adaptation to different environmental conditions.\u003cbr\u003e\nAlterations in Ten-1 expression or mutations can contribute to cancer progression and metastasis by affecting cell adhesion and migration. Studies indicate that lower levels of Ten-1 correlate with aggressive tumor phenotypes in breast and prostate cancers. Besides cancer Ten-1 interacts with proteins like vinculin which influences its role in tension transmission and force generation in cells potentially contributing to developmental disorders related to focal adhesion dysfunction. Understanding Ten-1's function in these contexts can offer insights into therapies targeting pathological cell migration and adhesion.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854120571049,"sku":"ab211297","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab211297","provider":"Iright","version":"1.0","type":"link"}