{"product_id":"abcam-ab211537","title":"Abcam, ab211537, Anti-REST \/ NRSF antibody [CL0381]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal REST \/ NRSF antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human REST aa 850-1000.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:CL0381,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human REST aa 850-1000. The exact immunogen used to generate this antibody is proprietary information.Q13127\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nREST also known as NRSF (neuron-restrictive silencer factor) is a transcriptional repressor weighing approximately 116 kDa. It regulates gene expression by binding to the RE1 silencing transcription factor (RE1-silencing element) in the DNA. REST is widely expressed in non-neuronal cells and plays a significant role in maintaining neuronal gene silencing in embryonic and adult stem cells. By interacting with co-repressors REST recruits histone deacetylases and methylases to modify chromatin structure effectively shutting down gene transcription in specific contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nREST regulates neuronal differentiation and plasticity by controlling the expression of neuronal-specific genes. It forms a complex with co-repressors such as mSin3 and CoREST participating in diverse biological processes including neurogenesis. REST expression is important for balancing the neuronal gene expression program preventing untimely or inappropriate activation of neuronal genes in non-neuronal tissues. By modulating the expression of synaptic proteins and neurotransmitter receptors REST influences synaptic plasticity and neuronal excitability.\u003cbr\u003e\nPathways\u003cbr\u003e\nREST participates in the neural stem cell differentiation pathway and cell fate determination. It interacts with pathways involving proteins such as HDAC1 and SWI\/SNF complexes contributing to chromatin remodeling and transcriptional regulation. Within these pathways REST ensures the maintenance of non-neuronal identity by repressing neuronal gene activation coordinating with other proteins to influence cellular outcomes and fate decisions.\u003cbr\u003e\nREST has been linked to neurological disorders such as Huntington's disease and epilepsy. In Huntington's disease REST dissociation from the Huntingtin protein increases leading to misregulation of neuronal genes and contributing to neurodegenerative changes. REST also plays a role in epilepsy where its dysregulation can lead to an imbalance in excitatory and inhibitory signals within the brain potentially triggering epileptic episodes. Through its interactions with disease-associated proteins REST exemplifies the complex interplay between transcriptional regulation and cellular dysfunction in disease pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854487769257,"sku":"ab211537","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab211537","provider":"Iright","version":"1.0","type":"link"}