{"product_id":"abcam-ab217347","title":"Abcam, ab217347, Anti-MKP-1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MKP-1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DUSP1 aa 150-250 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human DUSP1 aa 150-250 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P28562\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein known as MKP-1 also called DUSP1 is a dual-specificity phosphatase. It acts mechanically by dephosphorylating the phospho-tyrosine and phospho-serine\/threonine residues of its target proteins. The protein has a molecular weight of about 39 kDa. MKP-1 is ubiquitously expressed but shows higher levels in specific tissues such as liver lung and brain where it regulates various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMKP-1 influences cellular responses to stress and inflammation by inactivating mitogen-activated protein kinases (MAPKs). It does not exist as part of a permanent complex but temporarily interacts with MAPKs. By dephosphorylating these kinases MKP-1 modulates gene expression cell proliferation and apoptosis. Through these interactions the protein plays a significant role in protecting cells from excessive inflammatory signals and stress-induced damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe MKP-1 protein is integral to the MAPK signaling pathway and the JNK signaling cascade. MKP-1 directly affects the balance of MAPK-related proteins such as ERK JNK and p38 to help regulate various cellular outcomes. By dephosphorylating these proteins MKP-1 acts as a negative feedback regulator ensuring that cellular responses to external stimuli are controlled and do not become harmful.\u003cbr\u003e\nMKP-1 is associated with inflammatory diseases and cancer. Inflammatory disorders such as rheumatoid arthritis show link with aberrant regulation of MKP-1 as it often interacts with MAPKs involved in inflammation. In cancer altered MKP-1 expression can affect tumor growth and progression due to its regulatory role on cell proliferation pathways. The protein's interaction with key signaling molecules in these diseases highlights its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848579928233,"sku":"ab217347","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab217347","provider":"Iright","version":"1.0","type":"link"}