{"product_id":"abcam-ab218339","title":"Abcam, ab218339, Anti-Aurora B antibody [AURKB\/1521]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal Aurora B antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AURKB aa 50-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:AURKB\/1521,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human AURKB aa 50-300. The exact immunogen used to generate this antibody is proprietary information.Q96GD4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAurora B also known as Aurora kinase B or AURKB is a serine\/threonine protein kinase with a molecular mass of approximately 39 kDa. This protein expresses across various cell types and tissues playing a critical role during cell division. It localizes to the centromeres during early mitosis and later associates with the central spindle and midbody. Aurora B is a component of the chromosomal passenger complex (CPC) which includes other proteins such as INCENP survivin and borealin essential for its function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAurora B kinase functions to ensure proper chromosome alignment segregation and cytokinesis during mitosis and meiosis. It phosphorylates various substrates to facilitate processes like correction of kinetochore-microtubule attachments and regulation of the mitotic checkpoint. As a part of the CPC Aurora B acts in coordination with other proteins to control these cellular events ensuring that cells divide accurately and safely.\u003cbr\u003e\nPathways\u003cbr\u003e\nAurora B integrates into the cell cycle and mitotic pathways operating closely with the spindle assembly checkpoint. It interacts with proteins like CENP-A and CENP-E ensuring error-free chromosome segregation. Aurora B's activity within these pathways is critical for maintaining genomic stability and preventing aneuploidy a condition linked to improper chromosome number.\u003cbr\u003e\nAurora B's malfunction associates with cancer and chromosomal instability. Overexpression or dysregulation of Aurora B kinase frequently occurs in several types of cancer contributing to tumorigenesis by promoting abnormal cell division. Proteins such as p53 a well-known tumor suppressor often become functionally compromised when Aurora B activity is altered further advancing disease progression. Aurora B also holds implications in other disorders marked by faulty cell cycle regulation emphasizing its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855436075177,"sku":"ab218339","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab218339","provider":"Iright","version":"1.0","type":"link"}