{"product_id":"abcam-ab218531","title":"Abcam, ab218531, Anti-SEH1L antibody [EPR20851]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SEH1L antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 11 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20851,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSEH1L also known as SEH1 Nucleoporin is a protein that plays a mechanical role in the nuclear pore complex (NPC) which is involved in the transport of molecules between the nucleus and cytoplasm. It has a molecular mass of approximately 40 kDa. SEH1L is expressed in various tissues with notable expression in the liver kidney and spleen. In the cellular context it associates with other nucleoporins to form the NPC that spans the nuclear envelope facilitating the exchange of macromolecules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSEH1L contributes to the structural framework of the nuclear pore complex by being a part of the Nup107-160 subcomplex. This subcomplex is vital for maintaining NPC assembly and function. In addition to its structural role SEH1L influences the timing of mitotic spindle assembly and chromosome segregation. The protein is also implicated in the regulation of the cell cycle showcasing its importance in normal cellular operations.\u003cbr\u003e\nPathways\u003cbr\u003e\nSEH1L has involvement in the mTOR signaling pathway and the cell cycle control pathway. Within the mTOR pathway it works in coordination with proteins such as Raptor and mTORC1 linking nutrient availability to cell growth. In the cell cycle control pathway SEH1L impacts transitions between different phases by interacting with cyclin-dependent kinases and other regulatory proteins. These interactions highlight its role in ensuring proper cell cycle progression and preventing aberrant cell division.\u003cbr\u003e\nSEH1L is associated with cancer and developmental disorders. In cancer alterations in SEH1L and its related proteins like mTOR can lead to uncontrolled cellular proliferation and tumor growth. Developmental disorders related to faulty NPC components including SEH1L affect nucleocytoplasmic transport which may result in developmental delays and congenital anomalies. Understanding the function and regulation of SEH1L in these contexts offers potential insights for therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855874707625,"sku":"ab218531","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab218531","provider":"Iright","version":"1.0","type":"link"}