{"product_id":"abcam-ab220044","title":"Abcam, ab220044, Anti-ATP6J\/ATP6V1G1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ATP6J\/ATP6V1G1 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATP6V1G1 aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ATP6V1G1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O75348\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ATP6J\/ATP6V1G1 protein also known as V-type proton ATPase subunit G 1 is a component of the V1 domain of the vacuolar ATPase (V-ATPase) complex. The protein has a mass of roughly 13 kDa. It is expressed in various tissues with a higher abundance observed in the kidney and brain. The protein plays a role in the energy-dependent transport of protons across intracellular membranes an important component of cellular processes that require ATP hydrolysis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATP6V1G1 is part of the multi-subunit V-ATPase complex which functions as a proton pump to acidify intracellular compartments like lysosomes and endosomes. The complex enables the maintenance of microenvironments necessary for processes such as protein sorting zymogen activation and receptor-mediated endocytosis. By facilitating pH regulation within cells ATP6V1G1 supports essential cellular activities and homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nATP6V1G1 integrates into the acidification pathway linked to intracellular organelles. It also interfaces with the mTOR signaling pathway which depends on lysosomal acidification for its activation. The cooperation between V-ATPase and mTOR relates to other binding proteins and complexes involved in cellular growth and autophagy such as LAMP2 and LC3.\u003cbr\u003e\nDysfunctions in ATP6V1G1-associated pathways contribute to lysosomal storage disorders and renal tubular acidosis. Impaired V-ATPase function affects lysosomal enzyme activation and cellular trafficking. Additionally altered interactions between ATP6V1G1 and cystinosin a protein involved in cystinosis link the V-ATPase to pathological states within the kidneys impacting cellular waste processing.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854206357673,"sku":"ab220044","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab220044","provider":"Iright","version":"1.0","type":"link"}