{"product_id":"abcam-ab220753","title":"Abcam, ab220753, Anti-Nucleoside Diphosphate Kinase 7 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Nucleoside Diphosphate Kinase 7 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Nucleoside diphosphate kinase 7 aa 150-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Nucleoside diphosphate kinase 7 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q9Y5B8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNucleoside Diphosphate Kinase 7 also known as NME7 plays an important role in the catalysis of the transfer of gamma phosphate from nucleoside triphosphates to nucleoside diphosphates. This kinase part of the NM23 family comprises an approximate mass of 41 kDa and resides primarily in the human cytosol. Expression of NME7 occurs broadly in various tissues with notable amounts in the brain and liver. The presence of alternate names like NDPK 7 within scientific literature highlights its established relevance in the nucleoside diphosphate kinase activity field.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNucleoside diphosphate kinase facilitates regulation of cellular processes including cell proliferation differentiation and signal transduction. Though it does not traditionally form large protein complexes its actions link it indirectly to several molecular assemblies through substrate and product interactions. NME7 demonstrates additional roles in microtubule organization essential for cellular structural maintenance. Its ATP-binding and transfer capabilities make it an important player in maintaining cellular nucleotide balance.\u003cbr\u003e\nPathways\u003cbr\u003e\nNME7 engages in metabolic and signal transduction pathways that manage nucleotide synthesis and energy balance. In the purine metabolism pathway it functions alongside enzymes like guanylate kinase. NME7 also plays a role in the microtubule-associated regulation pathway affecting cell division and stability. By interacting with proteins such as tubulin it further integrates within the cytoskeletal dynamics system important for cell cycle progression and mitosis.\u003cbr\u003e\nNucleoside diphosphate kinase 7 implicates itself in neurodegenerative diseases and certain types of cancer. Its function in nucleotide balance and cell proliferation connects it to pathways disrupted in these diseases. Misregulation of NME7 has ties to Alzheimer's disease through its interaction with proteins involved in apoptosis and microtubule assembly like Tau protein. Additional links to cancer progression stem from alterations in its kinase activity often resulting in unchecked cellular growth in malignancies. Understanding these connections may present therapeutic opportunities targeting NME7-related pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854144557225,"sku":"ab220753","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab220753","provider":"Iright","version":"1.0","type":"link"}