{"product_id":"abcam-ab221161","title":"Abcam, ab221161, Anti-Rho A + B + C antibody [EPR18299] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RHOA antibody. Carrier free. Suitable for ICC\/IF, WB, Flow Cyt (Intra), IHC-P and reacts with Mouse, Human, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR18299,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab221161 is the carrier-free version of\u003cbr\u003e\nab188103\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRho proteins including Rho A B and C are small GTPases and part of the larger Rho family sometimes referred as Ras homologous proteins. They have a mass of approximately 21 kDa and play an important role in actin cytoskeleton dynamics. These proteins are primarily expressed in various tissues but are especially prevalent in the brain heart and lungs. When activated Rho proteins bind to GTP facilitating the reorganization of actin fibers critical for processes like cell movement and division.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRho proteins influence cell shape migration and adhesion. They are part of the Rho GTPase family which interacts with other molecules to form a complex that manages cellular structure. Rho proteins impact the formation of stress fibers and focal adhesions which are essential for maintaining tissue integrity and facilitating cellular responses. This activity makes Rho proteins vital players in wound healing and embryonic development.\u003cbr\u003e\nPathways\u003cbr\u003e\nRho proteins are critical parts of the Rho-ROCK (Rho-associated protein kinase) pathway and the Wnt signaling pathway. Both pathways are important for cell signaling that orchestrates changes in the cytoskeleton and cell behavior. In these pathways Rho proteins interact with kinases like ROCK1 and ROCK2 connecting to a larger network of signaling proteins that guide cellular outcomes involved in proliferation and structural maintenance.\u003cbr\u003e\nRho proteins have connections to cancer progression and cardiovascular diseases. Their role in cell adhesion and migration links them to metastasis where their dysregulation can promote tumor invasion. Also in cardiovascular conditions altered Rho activity impacts vascular smooth muscle contraction and endothelial function. Research associations identify proteins like E-cadherin in cancer and vascular endothelial cadherin in heart diseases as being influenced by Rho protein signaling.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851626565801,"sku":"ab221161","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab221161","provider":"Iright","version":"1.0","type":"link"}