{"product_id":"abcam-ab221931","title":"Abcam, ab221931, Anti-HEY2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal HEY2 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HEY2 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human HEY2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9UBP5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\n'HEY2' also known as 'heart and neural crest derivatives-expressed protein 2' or simply 'HEY’ or 'heytwo' is a transcription factor from the hairy and enhancer of split (HES) family. This protein has a molecular mass of approximately 37 kDa. It plays a significant role in the regulation of gene expression by binding to specific sequences in DNA. 'HEY2' gets expressed in different tissues particularly in heart vascular and neural crest-derived cells. Its expression appears during various stages of development and remains present in certain adult tissues underlining its continuing importance in cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\n'HEY2' participates in the regulation of cell differentiation and proliferation. It functions within the Notch signaling pathway and often associates with transcriptional repression complexes. 'HEY2' has the ability to modulate the activity of other transcription factors by influencing their binding efficiency. Through these interactions it helps establish cellular identities and maintain the balance between cell populations within developing tissues. Its involvement in cardiovascular development among others stands as a testament to its functional diversity.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein occupies an important position in the Notch signaling pathway and the TGF-beta signaling pathway. Within the Notch pathway 'HEY2' functions as a downstream effector that transduces signals necessary for cell fate determination. It is related closely to other Notch signaling components like JAG1 and DLL4. Additionally the interaction with the TGF-beta signaling pathway provides a link to cellular processes like apoptosis and epithelial-mesenchymal transition although the precise mechanisms demand further exploration.\u003cbr\u003e\nMutations and aberrant expression levels of 'HEY2' have been associated with congenital heart defects and cardiomyopathies. Its involvement with congenital heart defects is often observed with other proteins in the Notch pathway such as NOTCH1. Researchers find connections between 'HEY2' expressions and specific cardiovascular pathologies indicating its potential as a target for therapeutic interventions. Involvement in these conditions emphasizes the necessity for more detailed studies of this protein's behavior under pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854057296041,"sku":"ab221931","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab221931","provider":"Iright","version":"1.0","type":"link"}