{"product_id":"abcam-ab222129","title":"Abcam, ab222129, Anti-COX7A2L antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal COX7A2L antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human COX7A2L aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human COX7A2L aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O14548\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCOX7A2L also known as Cytochrome c oxidase subunit 7A-related protein or COX7AR is an important component of the mitochondrial respiratory chain. It has an approximate mass of 12.4 kDa. This protein is primarily expressed in tissues with high-energy demands such as the heart brain and skeletal muscle. COX7A2L is a mitochondrial outer membrane protein that is involved in the function of the electron transport chain where it facilitates the efficient transfer of electrons.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCOX7A2L engages in processes beyond its individual capabilities as it is a part of the supercomplex known as the respirasome. It modulates the stability and arrangement of complexes I III and IV within the mitochondrial electron transport chain. This protein plays a role in ATP production by optimizing the efficiency of electron transfer and reducing the generation of reactive oxygen species. Through these mechanisms COX7A2L supports energy metabolism and cellular respiration.\u003cbr\u003e\nPathways\u003cbr\u003e\nCOX7A2L influences both the oxidative phosphorylation pathway and the mitochondrial apoptosis pathway. It interacts with proteins such as Cytochrome c and ATP synthase to maintain effective energy conversion and to regulate programmed cell death processes. The function of COX7A2L ensures proper mitochondrial respiration which is critical for cell survival and energy output.\u003cbr\u003e\nCOX7A2L has associations with metabolic and neurodegenerative diseases including MELAS syndrome and Parkinson's disease. Alterations in COX7A2L can disrupt normal mitochondrial function which leads to deficits in energy metabolism. This protein is also linked to Cytochrome c through its role in apoptosis highlighting its significance in the pathology of diseases where mitochondrial dysfunction is a factor.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854175850665,"sku":"ab222129","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab222129","provider":"Iright","version":"1.0","type":"link"}