{"product_id":"abcam-ab222150","title":"Abcam, ab222150, Anti-GRIN1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GRIN1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GPRIN1 aa 400-550.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GPRIN1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q7Z2K8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGRIN1 also known as GluN1 represents a subunit of the NMDA receptor essential for normal synaptic function. This receptor weighs approximately 120 kDa and is mainly expressed in the brain where it plays an important role in excitatory neurotransmission. The receptor channels calcium sodium and potassium ions maintaining communication between neurons. GRIN1 combines with other subunits to form a functional receptor complex critical in mediating synaptic plasticity and memory function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGRIN1 binds with other NMDA receptor subunits to form a ligand-gated ion channel complex. The channel opens in response to glutamate binding allowing ions to flow through the membrane. This activity is fundamental for synaptic plasticity impacting processes like learning and memory. GRIN1 modulation affects activities at the synapse influencing both neuronal survival and excitatory signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nNMDA receptors involving GRIN1 participate in the glutamatergic neurotransmission pathway which is critical for excitatory synaptic transmission. These receptors associate with proteins like CaMKII linking them to the calcium signaling pathway. The proper functioning of this pathway is important for synaptic strength and development as dysregulation can lead to neurological issues.\u003cbr\u003e\nAberrations in GRIN1 activity relate to neurodegenerative and psychiatric disorders. Alzheimer's disease often shows disrupted NMDA receptor function where GRIN1 plays a role in amyloid-beta-mediated neuronal damage. Moreover dysregulation of GRIN1 is connected to schizophrenia where abnormal synaptic signaling alters brain function. Both diseases underline the importance of proper GRIN1 function in maintaining neural health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854226411689,"sku":"ab222150","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab222150","provider":"Iright","version":"1.0","type":"link"}