{"product_id":"abcam-ab222244","title":"Abcam, ab222244, Anti-DHX35 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DHX35 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DHX35 aa 600 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human DHX35 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H5Z1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDHX35 also known as DExH-box Helicase 35 is a member of the DEAD box protein family characterized by its Asp-Glu-Ala-Asp (DEAD) motif. This protein has a molecular mass of approximately 82 kDa. DHX35 functions mechanically as an ATP-dependent RNA helicase unfurling RNA secondary structures during processes such as transcription and translation. It is widely expressed in various tissues but notable expression occurs in the liver and testis. These helicases are important for manipulating RNA morphology to facilitate cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDHX35 has roles in RNA metabolism influencing processes such as RNA splicing and ribosome biogenesis. It doesn't operate alone; instead it integrates into intricate complexes with other proteins to regulate RNA dynamics. Its activity is important for proper RNA association with ribonucleoprotein complexes impacting RNA-mediated gene expression regulation and maintenance of cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nDHX35 contributes significantly to the RNA processing pathways particularly the RNA splicing pathway. Its interactions with proteins such as small nuclear ribonucleoproteins (snRNPs) highlight its participation in the spliceosome complex. Furthermore DHX35 also plays a part in ribosome biogenesis pathways linking to proteins such as nucleolin which assist in rRNA transcription and ribosomal assembly.\u003cbr\u003e\nDHX35 shows connections to genetic disorders like Male Infertility where dysregulation impacts sperm development and function. Additionally variations in DHX35 expression or function have associations with hepatocellular carcinoma suggesting a role in tumor biology. These associations stem from interactions with other proteins like DDX3X which also influence RNA processing in cancer and reproductive health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854235127977,"sku":"ab222244","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab222244","provider":"Iright","version":"1.0","type":"link"}